Anthelmintic effect of oxantel pamoate and pyrantel pamoate suspension against intestinal nematode infestations
Han-Jong Rim,Chang-Yong Won,Sung-Ik Lee and Jung-Kyoo Lim
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.
Department of Pharmacology, College of Medicine, Seoul National University, Seoul, Korea.
A total of 56 subjects with multiple nematode infections with T. trichiura, Ascaris, hookworms and Enterobius were treated with oxantel and pyrantel pamoate mixture in a paratable suspension(50 mg of each per ml).
A single dose of 10 mg per kg body weight in each cured 100 per cent of 54 subjects with Ascaris, 97.1 per cent of 35 subjects with hookworms, 77.8 per cent of 36 with Enterobius and 73.2 per cent of 56 subjects with T. trichiura infestation. The mean egg per gram stool reduction rate in T. trichiura infection was 91.9%. Of the 31 subjects infected with Ancylostoma doudenale 96.8% were cured with a single dose and 4 infected with Necator americanus showed a 100% cure rate with a similar daily dose on 3 consecutive days. Side effects were few and mild. There was no clinical or laboratory evidence of drug toxicity. These findings show a single dose of oxantel and pyrantel pamoate mixture to be a highly effective and acceptable treatment for multiple infections with these nematodes.
Table 1 Effect of a single dose of oxantel and pyrantel pamoate mixture (10mg/kg) against intestinal nematode infections
Table 2 Effect of a single dose of oxantel and pyrantel pamoate mixture against Trichuris trichiura by medication groups
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