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Korean J Parasitol > Volume 16(2):1978 > Article

Original Article
Korean J Parasitol. 1978 Dec;16(2):82-87. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1978.16.2.82
Copyright © 1978 by The Korean Society for Parasitology
Therapeutic effects of praziquantel (Embay 8440) against Hymenolepis nana infection
Han-Jong Rim,Chang-Yoon Park,Joon-Sang Lee,Kyoung-Hwan Joo and Kwang-Sa Lyu
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Korea.
Abstract

A total of 60 patients with Hymenolepis nana infection were treated with a single oral dose of praziquantel in two different dose levels. Twenty-nine cases treated with praziquantel in a single dose of 15 mg/kg body weight produced a 100% cure rate. On the otehr hand, 30 out of 31 patients who received a single dose of 25 mg/kg body weight cured completely, but only one case had counts of 200 EPG of feces in each tests on the 20th and 21st days after treatment. The cure rate was 96.8% and the mean egg reduction rate of 99.8 per cent was obtained.

Side effects were mild and transitory. In a few cases, abdominal pain, vertigo, headache and diarrhea were complained in a few hours after medication. Clinial hematology, serum biochemistry and urinalysis were performed immediately before and the next day after treatment in all cases. There were no significant abnormalities detected in these tests.

Tables


Table 1
Therapeutic effects of praziquantel (Embay 8440) against Hymenolepis nana


Table 2
Incidence of side effects

References
1. Ahkami S, Hajian A. Radical treatment of Hymenolepis nana with niclosamide. J Trop Med Hyg 1970;73(10):258–259.
 
2. Baranski MC. [Treatment of human taeniasis and hymenolepiasis with praziquantel (Embay 8440) (author's transl)]. Bol Chil Parasitol 1977;32(1-2):37–39.
 
3. Canzonieri CJ, Rodriguez RR, Castillo HE, Ibanez de, Lucena M. [Therapeutic trial with praziquantel in Taenia saginata and Hymenolepis nana infections (author's transl)]. Bol Chil Parasitol 1977;32(1-2):41–42.
 
4. The problem of treatment of cestodiasis. Bol Chil Parasitol 1977;32(1-2):1.
5. Diekmann HW, et al. European Jour of Drug Metabolism and Pharmacokinetice 1976;2:107–112.
 
6. Espejo H. [Treatment of infections by Hymenolepis nana, Taenia saginata, Taenia solium and Diphyllobothrium pacificum with praziquantel (Embay 8440) (author's transl)]. Bol Chil Parasitol 1977;32(1-2):39–40.
 
7. Groll E. [General scope of treatment with praziquantel (Embay 8440) in human cestode infections (author's transl)]. Bol Chil Parasitol 1977;32(1-2):27–31.
 
8. Kim CH, et al. Tonsei Report on Tropical Medicine 1971;2(1):30–43.
9. Machemer L, Lorke D. Mutagenicity studies with praziquantel, a new anthelmintic drug, in mammalian systems. Arch Toxicol 1978;39(3):187–197.
  
10. Mastrandrea G, et al. Arch Ital Sci Med Trop 1963;44:61–78.
11. Most H, Yoeli M, Hammond J, Scheinesson GP. Yomesan (niclosamide) therapy of Hymenolepis nana infections. Am J trop Med Hyg 1971;20(2):206–208.
 
12. Nagaty HF, et al. J Trop Med & Hyg 1962;56:128–129.
13. Obermeier J, Frohberg H. Mutagenicity studies with praziquantel, a new anthelmintic drug: tissue-, host-, and urine-mediated mutagenicity assays. Arch Toxicol 1977;38(3):149–161.
  
14. Perera DR, Western KA, Schultz MG. Niclosamide treatment of cestodiasis. Clinicial trials in the United States. Am J trop Med Hyg 1970;19(4):610–612.
 
15. Schenone H, Galdames M, Rivadeneira A, Morales E, Hoffmann MT, Asalgado N, Meneses G, Mora MV, Cabrera G. [Treatment of Hymenolepsis nana infection in children by a single oral dose of praziquantel (Embay 8440) (author's transl)]. Bol Chil Parasitol 1977;32(1-2):11–13.
 
16. Shafei AZ, Abaza HH. [N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamide in the treatment of Taenia saginata and Hymenolepis nana infection]. Z Tropenmed Parasitol 1962;13:194–198.
 
17. Steiner K, et al. Europ J of Drug Metabolism and Pharmacokinetics 1976;2:85–95.
 
18. Steiner K, et al. Europ J of Drug Metabolism and Pharmacokinetics 1976;2:97–106.
 
19. Thomas H. [Experimental results with praziquantel (Embay 8440) in cestodiasis and cysticercosis (author's transl)]. Bol Chil Parasitol 1977;32(1-2):2–6.
 
20. Yokogawa M, et al. Jap J Parasit 1962;11:387–389.
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