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Korean J Parasitol > Volume 26(3):1988 > Article

Original Article
Korean J Parasitol. 1988 Sep;26(3):175-178. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1988.26.3.175
Copyright © 1988 by The Korean Society for Parasitology
The wormicidal substances of fresh water fishes on Clonorchis sinensis VII. The effect of linoleic acid and ethyl linoleate on parasite viability
Jae Ku Rhee,Sang Bork Lee and Pyung Gil Kim
Department of Veterinary Parasitology, Chonbuk National University, Chonju 560-756, Korea.
Abstract

In an attempt to analyze the clonorchicidal activity of linoleic acid and ethyl linoleate in vitro, the wormicidal effects on Clonorchis sinensis were chronologically monitored in dose titration experiments. Excysted metacercariae were killed within a period of 31.0+-4.0 min, 149.3+-4.l min and 207.0+-13.5 min with 100.0 mg, 0.1 mg and 0.001 mg linoleic acid, respectively. The time required for the linoleic acid to kill adult worms was 167.0+-0.8 min with 100.0 mg, 253.0+-0.8 min with 0.1 mg, and 277.0+-0.8 min at 0.001 mg titration. Clonorchicidal activity of ethyl linoleate was relatively delayed as death was observed within 263.3+-2.9 min, 286.0+-0.5 min, and 318.0+-0.8 min for 100.0 mg/ml, 0.1 mg/ml and 0.001 mg/ml concentrations, respectively. The wormicidal effects observed with these pure anticlonorchal substances were found to be similar to the biological activity of native products derived from the mucus of the fresh water fish.

Figures


Fig. 1
Correlation of clonorchicidal activity with the concentration of linoleic acid.

Tables


Table 1
Clonorchicidal effects of linoleic acid on the adult of C. sinensis

References
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