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Korean J Parasitol > Volume 24(1):1986 > Article

Original Article
Korean J Parasitol. 1986 Jun;24(1):12-14. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1986.24.1.12
Copyright © 1986 by The Korean Society for Parasitology
Effect of flubendazole against Ascaris lumbricoides, Trichocephalus trichiurus and Enterobius vermicularis in infected children
Duk Young Min,Myong Hee Ahn and Kyong Min Kim
Department of Parasitology, Hanyang University Medical College, Korea.

Effectiveness of flubendazole, a newly introduced as an anthelmintic in Korea, was evaluated in 28 ascariasis, 28 whipworm infections and 17 pinworm infections in primary school children. All patients were orally given by flubendazole of 500 mg once. Stools for roundworm and whipworm and anal swabs for pinworm infections were examined both before and 25 days after treatment. After flubendazole treatment, all ascariasis and pinworm infected cases were cured. On the other hand, in whipworm infections, the cure rate was 82.1 percent (23 cured of 28 infected), and the egg reduction rate was 67.1 percent, respectively. Headache (one case), dizziness (2 cases) and abdominal pain (3 cases) were noticed as untoward effects, but they were mild and disappeared within 24 hours. These results demonstrate the excellent effectiveness of flubendazole in treating these helminth infections.


Fig. 1
Chemical structure of flubendazole (methyl-5-fluorobenzoyl benzimidazole-2-carbamate).


Table 1
Effectiveness of flubendazole against Ascaris lumbricoides, Trichocephalus trichiurus and Enterobius vermicularis in infected children*

1. Blechman MG, et al. Clin Res Reviews 1982;2(2):115–120.
2. Michiels M, et al. Arch intnl Pharmacodynamie et de Therapie 1982;256(2):180–191.
3. Soh CT, et al. Yonsei Rep Trop Med 1977;8(1):1–8.
4. Thienpont D, et al. Arzneim-Forsch/Drug Res 1978;28(1):4.
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