Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81

Warning: fopen(upload/ip_log/ip_log_2024-03.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83

Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84
Study on Metagonimus yokogawai(Katsurada, 1912) in Korea VII. Susceptibility of various strains of mice to Metagonimus infection and effect of Prednisolone
| Home | E-Submission | Sitemap | Contact us |  
top_img
Korean J Parasito Search

CLOSE

Korean J Parasito > Volume 22(2):1984 > Article

Original Article
Korean J Parasitol. 1984 Dec;22(2):153-160. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1984.22.2.153
Copyright © 1984 by The Korean Society for Parasitology
Study on Metagonimus yokogawai(Katsurada, 1912) in Korea VII. Susceptibility of various strains of mice to Metagonimus infection and effect of Prednisolone
Jong-Yil Chai,Byong-Seol Seo and Soon-Hyung Lee
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Seoul 110, Korea.
Abstract

An experimental study was undertaken to observe the difference in susceptibility of mouse strains to Metagonimus yokogawai infection by estimating it from worm recovery rate and dimension of worms. It was also studied the effects of prednisolone injection on the chronological pattern of worm recovery in ICR mice. The metacercariae were obtained from sweetfish and 300 in each number were given to 5 strains (CBH, A, DBA, C(57)BL and KK) of mice, and after 7 days period, the worms were collected from their intestine. Prednisolone at the dose of 10 mg/kg was injected to ICR mice every other day from 7 days prior to infection until sacrificed at 6 hours to 35th post-infection day. ICR mice infected with M. yokogawai but untreated were used for controls. The success rate in infection of mice ranged 25.0-83.3% by strains, the worm recovery rate 1.2-18.9%, and the average size of worms 0.554-0.683 mm long and 0.214-0.244 mm wide. The higher rates and larger size of worms were observed in KK and C(57)BL strains than others and the difference was statistically significant. In ICR mice for control, the worm recovery rate until 1 day after infection was relatively high (38-66%) but it became much lower (less than 0.7%) during 1-35 days. However, prednisolone injection brought about persistently high recovery rates (16-80%) until 21 days. It was concluded that the susceptibility to M. yokogawai infection is different by strains of mice but it can be elevated by prednisolone injection probably due to suppression of immune responses in ICR mice.

Figures


Fig. 1
Comparative worm recovery rate (M. yokogawai ) in perdnisolone-treated and untreated ICR mice.

Tables


Table 1
The rate of success in experimental infection of M. yokogawai to 5 strains of mice


Table 2
The result of worm recovery (M. yokogawai ) from 5 strains of experimental mice


Table 3
The measurements of M. yokogawai recovered from 5 strains of experimental mice


Table 4
The chronological worm recovery of M. yokogawai in two groups of mice (ICR) by location of worms in small intestine


Table 5
Differential leucocyte counts in ICR mice infected with M. yokogawai in comparsion with prednisolone-treated group

References
1. Chai JY. Seoul J Med 1979;20(2):104–117.
2. Coker CM. Effects of cortisone on Trichinella spiralis infections in nonimmunized mice. J Parasitol 1955;41(5):498–504.
  
3. COKER CM. Some effects of cortisone in mice with acquired immunity to Trichinella spiralis. J Infect Dis 1956;98(1):39–44.
  
4. Colley DG. Schistosoma mansoni: eosinophilia and the development of lymphocyte blastogenesis in response to soluble egg antigen in inbred mice. Exp Parasitol 1972;32(3):520–526.
  
5. Cross JH Jr. The natural resistance of the white rat to Nematospiroides dubius and the effect of cortisone on this resistance. J Parasitol 1960;46:175–185.
  
6. Cypess RH, Zidian JL. Heligmosomoides polygyrus (=Nematospiroides dubius): the development of self-cure and/or protection in several strains of mice. J Parasitol 1975;61(5):819–824.
  
7. Fischel EE, Vaughan JH, Photopoulos C. Inhibition of rapid production of antibody by cortisone; study of secondary response. Proc Soc Exp Biol Med 1952;81(2):344–348.
 
8. Germuth FG Jr, Ottinger B, Oyama J. Influence of cortisone on experimental hypersensitivity and circulating antibody in the guinea pig. Proc Soc Exp Biol Med 1952;80(2):188–191.
 
9. Gushima H. Igaku Kenkyu 1939;13(3):637–655.
10. Seo BS, Hong NT. Study On Metagonimus Yokogawai(Katsurada, 1912) In Korea: I. On The Metacercaria, Its Distribution In The Second Intermediate Host And The Development In The Final Host. Korean J Parasitol 1969;7(3):129–142.
 
11. Ito J. Progress of Med Parasit in Japan 1964;1:317–393.
12. Kagei N, et al. Bull Instit publ Hlth 1970;19(1):48–63.
13. Kang SY, Cho SY, Chai JY, Lee JB, Jang DH. A Study On Intestinal Lesions Of Experimentally Reinfected Dogs With Metagonimus Yokogawai. Korean J Parasitol 1983;21(1):58–73.
 
14. Koga G. Igaku Kenkyu 1983;12(10):3471–3528.
15. Lee BK. Yonsei J Med Sci 1968;1(1):110–119.
16. Lee CS. Theses of Catholic Med College 1967;12:103–117.
17. Lee CS. Theses of Catholic Med College 1967;12:119–129.
18. Lee SH, Song CY, Seo BS, Bae JH. [Studies On The Lungfluke, Paragonimus Iloktsuenensis: VI. Effect Of Prednisolone Injection On The Immune Responses Of Albino Rats]. Korean J Parasitol 1976;14(2):133–139.
 
19. Miller TA. J Parasit 1966;52:285–290.
 
20. Murrell KD, Clark S, Dean DA, Vannier WE. Influence of mouse strain on induction of resistance with irradiated Schistosoma mansoni cercariae. J Parasitol 1979;65(5):829–831.
  
21. Richards CS. Susceptibility of adult Biomphalaria glabrata to Schistosoma mansoni infection. Am J Trop Med Hyg 1973;22(6):748–756.
 
22. Richards CS, Merritt JW Jr. Genetic factors in the susceptibility of juvenile Biomphalaria glabrata to Schistosoma mansoni infection. Am J Trop Med Hyg 1972;21(4):425–434.
 
23. Seo BS, Lee SH, Cho SY, Chai JY, Hong ST, Han IS, Sohn JS, Cho BH, Ahn SR, Lee SK, Chung SC, Kang KS, Shim HS, Hwang IS. An Epidemiologic Study On Clonorchiasis And Metagonimiasis In Riverside Areas In Korea. Korean J Parasitol 1981;19(2):137–150.
 
24. Stirewalt MA, Shepperson JR, Lincicome DR. Comparison Of Penetration And Maturation Of Schistosoma Mansoni In Four Strains Of Mice. Parasitology 1965;55:227–235.
  
25. Stoner RD, Godwin JT. The effects of ACTH and cortisone upon susceptibility to trichinosis in mice. Am J Pathol 1953;29(5):943–950.
 
26. Tada I. Japanese J Parasit 1967;16(1):51–57.
27. Yokogawa M, et al. Japanese J Parasit 1968;17(6):540–545.
Editorial Office
Department of Molecular Parasitology, Samsung Medical Center, School of Medicine, Sungkyunkwan University,
2066 Seobu-ro, Jangan-gu, Suwon 16419, Gyeonggi-do, Korea.
Tel: +82-31-299-6251   FAX: +82-1-299-6269   E-mail: kjp.editor@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2024 by The Korean Society for Parasitology and Tropical Medicine.     Developed in M2PI