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Korean J Parasitol > Volume 21(2):1983 > Article

Original Article
Korean J Parasitol. 1983 Dec;21(2):241-245. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1983.21.2.241
Copyright © 1983 by The Korean Society for Parasitology
Praziquantel(Distocide®) in treatment of Clonorchis sinensis infection
Byong-Seol Seo,Soon-Hyung Lee,Jong-Yil Chai and Sung-Tae Hong
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Abstract

Praziquantel(Distocide®), the Korean product, was tested for its safety and efficacy in treatment of Clonorchis sinensis infection during the period from April to September, 1983 in Korea. A total of 55 egg positive cases were selected and treated with the regimen of 25 mg/kg t.i.d. for 1 day (total 75 mg/kg). The follow-up stool examination was done in 47 cases by cellophane think smear and Stoll's egg counting techniques. The 8 uncured cases were treated again with the same regimen. The laboratory tests for blood picture and liver function were done in 27 cases and compared before and after the treatment.

The results obtained are as follows:

1. After single course treatment, the cure and egg reduction rates were 83.0% and 99.1% respectively. With the second treatment, excellent results of 100% in both rates were obtained.

2. Several kinds of side effects such as dizziness, headache, etc. were complained by 29 cases (61.7%), however, those were so mild and transient that no special treatment was necessary.

3. No significant chang in laboratory findings was recognizable before and after the treatment.

From the above results, it is concluded that Distocide® is as effective and safe as Biltricide® and highly recommendable in treatment of C. sinensis infection.

Tables


Table 1
Cure rate of C. sinensis infection by praziquantel* treatment


Table 2
Distribution of treatment failure cases according to the degree of pre-treatment *E.P.G. value


Table 3
Egg reduction rate of C. sinensis by praziquantel treatment


Table 4
Number of patients who complained side effects following praziquantel treatment


Table 5
Laboratory findings in the patients before and after treatment with praziquantel

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