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Korean J Parasitol > Volume 18(2):1980 > Article

Original Article
Korean J Parasitol. 1980 Dec;18(2):145-151. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1980.18.2.145
Copyright © 1980 by The Korean Society for Parasitology
Comparative efficacy of interval mass treatment on Ascaris lumbricoides infection in Korea
Byong-Seo Seo,Seung-Yull Cho,Jong-Yil Chai and Sung-Tae Hong
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Abstract

To observe the effect of various interval mass treatment on Ascaris ova and worm positive rates and worm burden per population, 2-month, 4-month, 6-month and 12-month interval schemes were designed and applied. All of inhabitants in nine villages of Hwasung Gun, Kyunggi Do, Korea were treated from April 1977 to May 1980.

Each village consisted of 100~140 people, however, there had been 20~40 drop-outs in every treatment. Pyrantel pamoate was used in dose of 10 mg/kg. Evaluation of schemes was made by examinations both for eggs and for expelled worms. The drop-outs in former treatment was included because they were few in munber. The reults obtained were summerized as follows:

1. The pre-treatment infection status of A. lumbricoides was not significantly different between Groups; 32.5-42.2% and 33.8-46.2% in egg and worm positive rates respectively. The mean worm burdens were in range, 1.6~4.2 per infected and 0.61~1.42 per population.

2. Twelve-month interval treatment was by no means meaningful to be adopted as a strategy of Ascaris control because egg and worm positive rates and worm burden were returned to pretreatment level.

3. The shorter the treatment interval was, the lower the egg/worm positive rates and worm burden were. By repeating biannual, triannual and six-times-in-a-year treatments, the indices of prevalence showed the tendency of further lowering during later 2 years of follow-up.

If the mass chemotherapy is adopted as a method of controlling ascariasis in a community, it should be repeated more than two times in a year to expect the gradual lowering of reinfection.

Figures


Fig. 1
Comparative efficacy of various interval mass chemotherapy revealed by egg positive rate.


Fig. 2
Mean worm burden per population during the course of various interval mass treatment.

Tables


Table 1
Infection status of Ascaris lumbricoides revealed by egg and worm examinations in 2-month interval treatment group*


Table 2
Infection status of Ascaris lumbricoides revealed by egg and worm examinations in 4-month interval treatment group


Table 3
Infection atatus of Ascaris lumbricoides revealed by egg and worm examinations in 6-month interval treatment group*


Table 4
Infection atatus of Ascaris lumbricoides revealed by egg and worm examinations in 12-month interval treatment group*

References
1. Arfaa F, Ghadirian E. Epidemiology and mass-treatment of ascariasis in six rural communities in central Iran. Am J Trop Med Hyg 1977;26(5 Pt 1):866–871.
 
2. Cabrera BD, Arambulo PV 3rd, Portillo GP. Ascariasis control and/or eradication in a rural community in the Philippines. Southeast Asian J Trop Med Public Health 1975;6(4):510–518.
 
3. Desowitz RS, Bell T, Williams J, Cardines R, Tamarua M. Anthelmintic activity of pyrantel pamoate. Am J Trop Med Hyg 1970;19(5):775–778.
 
4. Jancloes MF, Cornet P, Thienpont D. Mass control of ascariasis with single oral doses of levamisole. A controlled comparison in 3,056 subjects between three incomplete population coverages. Trop Geogr Med 1979;31(1):111–121.
 
5. Mackay DM, et al. Health and Hygiene 1979;2:123–125.
6. Morishita K. Progress of Med Parasitology in Japan 1972;4:1–153.
7. Seo BS, et al. Korean Central J Med 1972;17:11–18.
8. Seo BS, Cho SY, Chai JY. [Seasonal Fluctuation Of Ascaris Reinfection Incidences In A Rural Korean Population]. Korean J Parasitol 1979;17(1):11–18.
 
9. Seo BS, Chai JY. Effect Of Two-Month Interval Mass Chemotherapy On The Reinfection Of Ascaris Lumbricoides In Korea. Korean J Parasitol 1980;18(2):153–163.
 
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