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Korean J Parasitol > Volume 13(2):1975 > Article

Original Article
Korean J Parasitol. 1975 Dec;13(2):123-132. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1975.13.2.123
Copyright © 1975 by The Korean Society for Parasitology
Effectiveness of anthelmintic drugs against Clonorchis sinensis infection of rabbits
Han-Jong Rim,Dong Shik Chang,Il Hyun and Sun-Dae Song
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.
Abstract

In order to find a highly efficient compound against Clonorchis infection, the anthelmintic activity of disophenol, Tremerad (SYD-230), dithiazanine iodide, dehydroemetine-late-release tablets(RO 1-9334/20), niridazole (Ambilhar), hexachlorophene (G-11), Hetol(1, 4-bis-trichloromethylbenzol) and Bilevon (niclofolan) was tested against Clonorchis sinensis experimentally infected rabbits. All drugs showed a progressive increase in efficacy as the dose rate. They were highly efficient against Clonorchis infection if sufficiently high, potentially toxic doses were given.

The efficacy was evaluated by the number of detected worms with vital condition at autopsy after the treatment with above drugs. The high efficacy was observed at the following dose rates of each drugs, i.e. disophenol at a single dose of 30 mg/kg, Tremerad at the daily dose of 200 mg/kg for 10 consecutive days, dithiazanine iodide at the daily dose of 50 mg/kg for 6 consecutive days, dehydroemetine at the daily dose of 10 mg/kg for 10 consecutive days, hexachlorophene at the daily dose of 20 mg/kg for 10 to 15 consecutive days, Hetol at the daily doses from 50 to 100 mg/kg for 5 to 10 consecutive days, and Bilevon at a single dose of 8 mg/kg. Moderate effectiveness was shown in niridazole at the dose of 25 mg/kg for 10 days medication.

The use of these anthelmintics for the clinical treatment of Clonorchis sinensis infection is discussed.

Tables


Table 1
Effects of various drugs on C. sinensis in experimentally infected rabbits with 500 metacercariae


Table 2
Effects of hexachlorophene on C. sinensis in experimentally infected rabbits with 500 metacercariae


Table 3
Effects of Hetol on C. sinensis in experimentally infected rabbit with 500 metacercariae


Table 4
Effects of Bilevon on C. sinensis in experimentally infected rabbit with 500 metacercariae

References
1. Aguilar FJ. The polyanthelmintic action of dithiazanine iodide; verification of its effectiveness in the most common helminthiases in Guatemala. Am J Trop Med Hyg 1959;8(3):305–306.
 
2. Arfaa F, Bijan H, Sadeghi A. Mass chemotherapy of urinary bilharziasis with a nitrothiazolyl compound (Ambilhar). Trans R Soc Trop Med Hyg 1967;61(5):653–658.
  
3. Boray JC, et al. Veterinary Record 1967;80:218–224.
4. Boray JC, Happich FA. Standardised chemotherapeutical tests for immature and mature Fasciola hepatica infections in sheep. Aust Vet J 1968;44(2):72–78.
  
5. Brown HW. Anthelmintics, new and old. Clin Pharmacol Ther 1969;10(1):5–21.
 
6. Campbell A, Martin MK, Farrington KJ, Erdelyi A, Johnston R, Sorby P, Whitlock HV, Pearson IG, Jones RC, Haigh JA, Degoosh CP. A new compound effective against acute fascioliasis in sheep. Experientia 1967;23(12):992–993.
  
7. Cho KM, Kim CH, Ahn YK, Soh CT. Experimental Studies Of 1, 4-Bis-Trichlormethyl-Benzol On The Infection Of Clonorchis Sinensis(I). Korean J Parasitol 1966;4(1):11–20.
 
8. Cho MJ, Cho KM, Soh CT. The Use Of Hetol On The Infection Of Clonorchis Sinensis. Korean J Parasitol 1966;4(1):21–31.
 
9. Chung HL, et al. Chinese Med J 1963;82:697–701.
10. Frye WW, Swartzwelder C, Lampert R, Abadie SH, Carson CB Jr. An effective trichuricide suitable for oral administration. Am J Trop Med Hyg 1957;6(5):890–893.
 
11. Gelfand M, Reid ET, Simpson BE. A trial with dehydro-emetine in schistosomiasis in Rhodesia. Trans R Soc Trop Med Hyg 1962;56:77–80.
  
12. Harinasuta C, et al. Trans Roy Soc Trop Med Hyg 1966;90:690.
 
13. Huang SW, et al. Chinese Med Journal Rep of China 1965;12:68–79.
14. Lim YC, et al. Korean Centr J Med 1964;6:145–155.
15. McCowen MC, Callender ME, Brandt MC. The anthelmintic effect of dithiazanine in experimental animals. Am J Trop Med Hyg 1957;6(5):894–897.
 
16. Powell SJ, McLeod I, Wilmot AJ, Elsdon-Dew R. Dehydroemetine in amebic dysentery and amebic liver abscess. Am J Trop Med Hyg 1962;11:607–609.
 
17. Rim HJ. Korea Medical Journal 1975;12:425–457.
18. Swartzwelder JC, et al. JAMA 1957;165:2063–2067.
19. Swartzwelder JC, Lampert R, Miller JH, Sappenfield RW, Frye WW, Abadie SH, Coco LJ. Therapy of trichuriasis and ascariasis with dithiazanine. Am J Trop Med Hyg 1958;7(3):329–333.
 
20. Wagner ED, Lemon FR, Burnett HS. The use of dithiazanine in the treatment of helminthiasis in Mexican farm laborers. Am J Trop Med Hyg 1958;7(6):600–602.
 
21. Wood IB, Pankavich JA, Wall Ace WS, Thorson RE, Burkhart RL, Waletzky E. Disophenol, an injectable anthelmintic for canine hookworms. J Am Vet Med Assoc 1961;139:1101–1105.
 
22. Yamaguchi T, et al. Tokushima Jour of Experimental Medicine 1962;8:307–334.
23. Yokogawa M, et al. Jpn J Parasit 1965;14:233–242.
24. Yokogawa M, et al. Jpn J Parasitology 1965;14:526–533.
25. Yokogawa M, et al. Z Tropenmed Parasit 1967;18:82–88.
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