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Korean J Parasitol > Volume 4(1):1966 > Article

Original Article
Korean J Parasitol. 1966 Aug;4(1):21-31. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1966.4.1.21
Copyright © 1966 by The Korean Society for Parasitology
The use of Hetol on the infection of Clonorchis sinensis
Moo-Joon Cho,Kee-Mok Cho and Chin-Thak Soh
Department of Parasitology, Yonsei University Colege of Medicine, Korea.
Abstract

The 16 cases of Clonorchis sinensis infection were divided into 6 groups, according to the method of administration of 1, 4-Bis-trichlormethyl-benzol. The number of egg-out and clinical manifestation of pre and post drug administration were observed.

1. In all groups, the number of ova transiently increased at the early stage of treatment and followed rather abrupt decrease reaching to E.P.G. zero by Stoll's method on 4 weeks after the medication, except group 6 which showed a few ova by M.G.L. method.

2. Subjective symptoms: fatigability, disappetite and other general complaints by the drug administration were markedly improved in all cases.

3. Blood counts and bleeding time were within normal value before and after the treatment.

4. Liver function test was normal during pre- and post-treatment except case No. 9. Serum alkaline phosphatase of No.9 was high level lbefore treatment, but recovered to noraml level 3 weeks later of the drug administrations.

5. SGOT and SGPT in 10 cases examined showed normal value.

6. The level of serum protein was not changed during observation period.

7. Urine albumin was noted in 2 cases before medication, but they also converted to negative within 3 weeks. Serum creatinine were all normal limits.

8. Bradycardia were noted in 2 cases during observed no significant abnormalities of EKG.

9. Serum electrophoresis were also normal limits.

Tables


Table I
Administration of 1,4-Bis-trichlormethyl-benzol to the Clonorchiasis Patients


Table II
Number of clonorchis eggs before and after the administration of 1,4-Bis-trichlormethyl-benzol


Table III
Symptoms and signs before and after administration of 1,4-Bis-trichlormethyl-benzol to clonorchiasis patients


Table IV
Vital signs and complaints before and after the administration of 1,4-Bis-trichlormethyl-benzol to clonorchiasis patients


Table V
Hematological study before and after the administration of 1,4-Bis-trichlormethyl-benzol to clonorchiasis patients


Table VI
Serum protein; before and after the administration of 1,4-Bis-trichlormethyl-benzol to clonorchiasis


Table VII
Liver function tests before and after the administration of 1,4-Bis-trichlormethyl-benzol to clonorchiasis patients


Table VIII
E. K. G. before and after the administrationof 1,4-Bis-trichlormethyl-benzol to clonorchiasis patients


Table IX
Electrolyte and creatinin of 1,4-Bis-trichlormethyl-benzol treated clonorchis sinensis infected cases

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