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Korean J Parasitol > Volume 26(1):1988 > Article

Original Article
Korean J Parasitol. 1988 Mar;26(1):1-8. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1988.26.1.1
Copyright © 1988 by The Korean Society for Parasitology
Changes of anti-Clonorchis sinensis IgG antibody in serum after praziquantel treatment in human clonorchiasis
Sung Tae Hong
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Seoul, 110-460, Korea.
Abstract

Anti-Clonorchis IgG antibody levels in serum were observed by ELISA in 129 egg positive cases and in 25 controls. The antibody levels were 0.063 to 1.216 (0.325±0.202)in clonorchiasis cases and 0.078 to 0.670 (0.255±0.133) in controls. The difference was statistically significant. However, serological diagnosis of clonorchiasis was not satisfactory in lightly infected cases because of low levels of specific IgG antibody. The antibody levels were well correlated with EPG. Changes of the IgG antibody levels were not significant 12-14 days, 4 weeks and 8-9 weeks after praziquantel treatment. Seven and 13 months after treatment, the IgG antibody levels were lowered significantly. The period for serologically negative conversion after praziquantel treatment was between 9 weeks and 7 months in human clonorchiasis.

Figures


Fig. 1
Anti-Clonorchis IgG antibody levels by ELISA plotted by grade of EPG.


Fig. 2
Changes of Anti-Clonorchis IgG antibody levels in serum by ELISA after treatment by Group(Group I-C; pre-treatment of Group I, I-T; 12-14 days after treatment, Group II-C; pre-treatment of Group II, II-T; 4-6 weeks after treatment, Group III-C; pre-treatment of Group III, III-T; 8-9 weeks after treatment, Group IV-C; pre-treatment of Group IV, IV-T; 7 months after treatment, Group V-C; pre-treatment of Group V, V-T; 13 months after treatment).

Tables


Table 1
Anti-Clonorchis IgG antibody levels by ELISA in C. sinensis egg positive cases and controls


Table 2
Anti-Clonorchis IgG antibody levels in serum by EPG grades in clonorchiasis cases


Table 3
Changes of anti-Clonorchis IgG antibody after praziquantel treatment in various groups

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