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Korean J Parasitol > Volume 4(1):1966 > Article

Original Article
Korean J Parasitol. 1966 Aug;4(1):53-57. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1966.4.1.53
Copyright © 1966 by The Korean Society for Parasitology
Treatment of hookworm infection with 2, 6-Diiodo-4-Nitrophenol
Chin-Thack Soh, M.D., D.M.Sc.,Moo-Joon Cho, M.D.,Yong-Hee Rho, M.D. and Jae-Heung Lee, M.D.
Department of Parasitology, Yonsei University College of Medicine, Seoul, Korea.

Single dose(1.0 cc) of 20% 2, 6-diiodo-4-nitrophenol solution was injected to 82 hookworm infected cases and 79% of them became egg-negative within 2-3 weeks after the injection. Mild to severe local pain were experienced for several minutes in all cases. Two cases complained of paralysis of the arms of the same side. The tablet of the same formula was given orally to 21 cases for 1-4 days. The 2-4 day course with 360 mg/day were enough to eliminate the parasite, and showed no systemic side effects.


Table 1
Parasitological and pathological examination of bookworm infected dogs which were injected with 3.5% 2,6-diiodo-4nitrophenol solution

Table 2
Parasitological and clinical examination of bookworm infected cases who were injected with 1 c.c. of 20% 2,6-diiodo-4nitrophenol solution

Table 3
Oral administration of 2,6-diiodo-4nitrophenol to hookworm infectedcases

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4. Darne A, et al. Veterinary Record 1964;76(6):171–172.
5. Huang SW, et al. Chinese Med J Republic of China 1965;12:68–79.
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