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Korean J Parasitol > Volume 20(2):1982 > Article

Original Article
Korean J Parasitol. 1982 Dec;20(2):75-82. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1982.20.2.75
Copyright © 1982 by The Korean Society for Parasitology
Influence of transferred anti-Nematospiroides dubius immune serum and IgG on immune reaction in recipient mice
Keuk Seung Bang
College of Agriculture, Dong-A University, Busan 600-02, Korea.

The effect of transferred immune serum and IgG on the response of recipient mice to concurrent infections with larvae has been investigated.

Following one infection, recipient mice harboured fewer worms than control mice, the worms were stunted and thier fecundities were greatly reduced.

Four concurrent infections was found to reduce worm burden and worm fecundity, and induce an increase of serum antibody titers in no-treatment and normal serum given mice.

On the other hand the transferred immune serum and IgG appeared to adversely affect the protective immune response in recipient mice. In recipient mice, worm fecundity was consistently increased throughout experiment and harboured more worms after four infections than control mice.

Serum anti-N. dubius antibody titers of mice made passively immune by transfer of immune serum and IgG were not significant difference between one infection and four infections.

Thus, transferred immune serum and IgG may debilitate host antibody production.


Fig. 1
Fractionation diagram for IgG from immune serum.

Fig. 2
The pattern of egg production in groups of mice given immune serum, IgG, normal serum and no-treatment.

(▲) Immune serum; (□) IgG; (●) Normal serum; (○) No-treatment


Table 1
The effect of transferred immune serum and IgG on the survival of Nematospiroides dubius in mice given concurrent infections with 120 larvae

Table 2
The effect of transferred immune serum and IgG on the worm length from mice given concurrent infections with 120 larvae

Table 3
Anti-Nematospiroides dubius antibody titers in sera of mice given concurrent infections with 120 larvae

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