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Korean J Parasitol > Volume 20(1):1982 > Article

Original Article
Korean J Parasitol. 1982 Jun;20(1):1-8. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1982.20.1.1
Copyright © 1982 by The Korean Society for Parasitology
Therapeutic field trial with praziquantel (Biltricide®) in a rural population infected with Clonorchis sinensis
Han-Jong Rim,Young-Man Lee,Joon-Sang Lee and Kyoung-Hwan Joo
Department of Parasitology and Institute of Tropical Endemic Diseases, College of Medicine, Korea University, Korea.
Abstract

The present study was undertaken to determine the acceptablility, tolerance and effectiveness of praziquantel in a rural population infected with Clonorchis sinensis and to suggest the suitable dosages of praziquantel for the field use on a large scale.

A total of 121 patients with proven C. sinensis infection were treated by two dosages with praziquantel at a single dose of 40 mg/kg bwt and 2 doses of 30 mg/kg bwt in a single day. A single dose of 40 mg/kg bwt were given to 60 patients and 2 × 30mg/kg bwt were given to 61 patients. Follow-up examinations were carried out at about 30 and 60 days after treatment. Two months after therapy, 13(21.7%) of 60 patients who received a single dose of 40 mg/kg bwt were cured completely. Among these cured patients, 9(75.0%) out of 12 cases of light and only 4 out of 48 cases of moderate or heavy infection groups were cured. But in the non-cured cases the overall egg reduction rate was 89.1%. On the other hand, 36(59.0%) out of 61 patients treated with 2 × 30mg/kg bwt were cured at 60 days after treatment. Among these cured patients, all of the 13 cases of light infection and 18(69.2%) out of 26 cases of moderate and 5(23.8%) out of 21 cases of heavy infection groups were cured completely at 60 days after therapy. However the overall egg reduction rate was 95.2% in the non-cured cases.

Praziquantel is well tolerated and side effects consist particularly of mild and transient headache, dizziness and abdominal discomfort, etc. However there was no difference in regard to frequency and intensity of untoward side effects between the two dosage groups.

The results obtained in this study suggest that a single dose of 40 mg/kg bwt for light infection, 2 × 30mg/kg bwt for moderate infection and 3 × 25mg/kg bwt for heavy infection groups will be recommended for the field use on a large scale.

Tables


Table 1
Number of patients in the study group in relation to the intensity of infection and allocation to dosages


Table 2
Therapeutic effect of praziquantel (Biltricide) in clonorchiasis


Table 3
The evaluation of the effectiveness in the use of praziquantel to clonorchiasis patients


Table 4
Frequency of symptoms in clonorchiasis patients after treatment with praziquantel

References
1. Davis A, Biles JE, Ulrich AM. Initial experiences with praziquantel in the treatment of human infections due to Schistosoma haematobium. Bull World Health Organ 1979;57(5):773–779.
 
2. Katz N, Rocha RS, Chaves A. Preliminary trials with praziquantel in human infections due to Schistosoma mansoni. Bull World Health Organ 1979;57(5):781–785.
 
3. Kim SS, et al. Korea Univ Med J 1982;19:91–105.
 
4. Rim HJ, Chu DS, Lee JS, Joo KH, Won CY. [Anthelmintic Effects Of Various Drugs Against Metagonimiasis]. Korean J Parasitol 1978;16(2):117–122.
 
5. Rim JH, et al. Korea Univ Med J 1979;16:459–470.
6. Rim HJ, Ha JH, Kim SJ. [Experimental study on the therapeutic effect of praziquente1(Embay 8440) in rats experimentally infected with Clonorchis sinensis]. Korean J Parasitol 1980;18(1):65–80.
 
7. Rim HJ, et al. Korea Univ Med J 1980;17:113–128.
8. Rim HJ, Lyu KS, Lee JS, Joo KH. Clinical evaluation of the therapeutic efficacy of praziquantel (Embay 8440) against Clonorchis sinensis infection in man. Ann Trop Med Parasitol 1981;75(1):27–33.
 
9. Rim HJ, et al. New Med J 1981b;24:255–262.
10. Rim HJ, Park HY, Kim SJ, Lee SH. [Morphological Observations On Clonorchis Sinensis Obtained From Rats Treated With Praziquantel]. Korean J Parasitol 1980;18(2):192–198.
 
11. Rim HJ, Chang YS, Lee JS, Joo KH, Suh WH, Tsuji M. Clinical Evaluation Of Praziquantel(Embay 8440; Biltricide(R)) In The Treatment Of Paragonimus Westermani. Korean J Parasitol 1981;19(1):27–37.
 
12. Santos AT, Blas BL, Noseñas JS, Portillo GP, Ortega OM, Hayashi M, Boehme K. Preliminary clinical trials with praziquantel in Schistosoma japonicum infections in the Philippines. Bull World Health Organ 1979;57(5):793–799.
 
13. Soh CT, et al. Yonsei Rep Trop Med 1979;10:22–28.
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