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Korean J Parasitol > Volume 16(1):1978 > Article

Original Article
Korean J Parasitol. 1978 Jun;16(1):21-25. Korean.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1978.16.1.21
Copyright © 1978 by The Korean Society for Parasitology
Reduced single dose of mebendazole in treatment of Ascaris lumbricoides infection
Byong-Seol Seo,Seung-Yull Cho and Jong-Yil Chai
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Abstract

The efficacy of reduced single doses of mebendazole against Ascaris lumbricoides infection was evaluated by cellophane thick smear and egg counting techinques, in two rural populations from December 1977 to March 1978.

Total 191 infected cases were divided into five dose groups; 100 mg single dose, 200 mg single dose, 300 mg single dose, 400 mg and 600 mg in repeated doses.

The cure rate of mebendazole in the treatment of Ascaris infection was remarkably high and satisfactory in every dose groups. The egg reduction rates were all over 98 percent in every dose groups.

Side effects were observed during the treatment, mainly mild and transient gastrointestinal troubles, and not exacerbated by the increase of doses upto 300 mg in single dose.

Above results confirmed that in case of mass chemotherapy of Ascaris infection, 100 mg or 200 mg of single dose treatment is sufficient to achieve the economic and acceptable method of treatment.

Tables


Table 1
Results of stool examination in two surveyed inhabitants revealed by cellophane thick smear method


Table 2
Cure rate of Ascaris lumbricoides infection by dosage schedules of mebendazole


Table 3
Distribution of failed cases in complete cure according to the age band of subjected cases by doses


Table 4
Egg reduction rates Ascaris lumbricoides according to doses of mebendazole


Table 5
Distribution of failed cases in complete cure according to the pre-treatment E.P.G.

References
1. Brugmans JP, Thienpont DC, van Wijngaarden I, Vanparijs OF, Schuermans VL, Lauwers HL. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects. JAMA 1971;217(3):313–316.
  
2. Partono F, Purnomo, Tangkilisan A. The use of mebendazole in the treatment of polyparasitism. Southeast Asian J Trop Med Public Health 1974;5(2):258–264.
 
3. Chavarria AP, Swartzwelder JC, Villarejos VM, Zeledon R. Mebendazole, an effective broad-spectrum anthelmintic. Am J trop Med & Hyg 1973;22(5):592–595.
4. Seo BS, Cho SY, Kang SY, Chai JY. Anthelmintic Efficacy Of Methyl-5-Benzoylbenzimidazole-2-Carbamate(Mebendazole) Against Multiple Helminthic Infections. Korean J Parasitol 1977;15(1):11–16.
 
5. Sho CT, et al. Yonsei Rept Trop Med 1974;5:148–152.
6. Wolfe MS, Wershing JM. Mebendazole. Treatment of trichuriasis and ascariasis in Bahamian children. JAMA 1974;230(10):1408–1411.
  
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