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Korean J Parasitol > Volume 14(1):1976 > Article

Original Article
Korean J Parasitol. 1976 Jun;14(1):25-31. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1976.14.1.25
Copyright © 1976 by The Korean Society for Parasitology
Clinical trial of oxantel pamoate(CP-14, 445) on Trichocephalus trichiurus infection
Soon-Hyung Lee,Byong-Seol Seo,Seung-Yull Cho and Shin-Yong Kang
Department of Parasitology, College of Medicine, Chung-Ang University, Seoul, Korea.
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Abstract

The present clinical trial was conducted to determine the efficacy and tolerance of oxantel(CP-14, 445), one of pyrimidine derivative, in the treatment of Trichocephalus trichiurus infection. One hundred eighty two cases who harboured T. trichiurus were treated with oxantel in a single dose of 10 to 25 mg/kg of body weight. For the evaluation, the negative conversion rate and egg reduction rate were calculated before and 22 days after the treatment. The results obtained were as follows: The prevalence rate of T. trichiurus infection in present study was 64.2% by examining 1,536 fecal specimens collected. The overall negative conversion rate was 66.5%, while the highest rate(93.3%) was obtained in the group treated with 20 mg/kg of oxantel (Group III). The lowest rate(56.6%) was observed in Group I (10 mg/kg). The overall egg reduction rate on present study was 90.3%. The highest rate, 100% of egg reduction was also obtained in Group III (20 mg/kg). From the observation of 1,244 expelled worms, it was known that 45.0% of collected worms were expelled on the first of post-treatment day, and male and female worms were about the same in number(1.03 : 1). Average worm burden per capita was 11.1 in this observation. The medication was readily accepted and tolerated by all the treated cases. On the hemograms, urinalysis and liver function tests, no significant differences were noted before and after the drug administration. Side reactions were so mild and transient that none required specific treatment.

Tables


Table 1
Prevalence of Trichocephalus trichiurus infection in various groups


Table 2
Classification and doses of antiwhipworm treatment with Oxantel pamoate (CP-1445)


Table 3
Egg negative conversion rates of T. trichiurus on egg counting at the 22nd post-treatment day by Oxantel treatment


Table 4
Egg reduction rates of T. trichiurus at the 22nd post-treatment day by Oxantel treatment


Table 5
Distribution of T. trichiurus egg counts by grades before and 22 days after the Oxantel treatment


Table 6
Expelled worms after the Oxantel treatment

References
1. Howes HL Jr. Trans-1,4,5,6-tetrahydro-2-(3-hydroxystyryl)-1-methyl pyrimidine (CP-14,445), a new antiwhipworm agent. Proc Soc Exp Biol Med 1972;139(2):394–398.
  
2. Huang WH, Brown HW. Clinical Trials of Stilbazium Iodide (Monopar) in the Treatment of Trichuris and Ascaris Infections. Am J Trop Med Hyg 1964;13:54–56.
 
3. Jung RC, Beaver PC. Clinical observations on Trichocephalus trichiurus (whipworm) infestation in children. Pediatrics 1951;8(4):548–557.
 
4. Lim JK. Korean J Pharmacol 1974;10:97–101.
5. Park CW, et al. Seoul J Med 1973;14:228–232.
6. Seo BS, Rim HJ, Loh IK, Lee SH, Cho SY, Park SC, Bae JW, Kim JH, Lee JS, Koo BY, Kim KS. [Study On The Status Of Helminthic Infections In Koreans]. Korean J Parasitol 1969;7(1):53–70.
 
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