| Home | E-Submission | Sitemap | Contact us |  
Korean J Parasitol > Volume 12(2):1974 > Article

Original Article
Korean J Parasitol. 1974 Dec;12(2):135-140. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1974.12.2.135
Copyright © 1974 by The Korean Society for Parasitology
Clinical trial of Tinidazole (Fasigyn) in acute and chronic intestinal amoebiasis
Jung-Kyoo Lim
Department of Pharmacology, College of Medicine, Seoul National University, Korea.

Tinidazole (Fasigyn), a new drug which is active in vitro and in vivo against Entamoeba histolytica, was used in 30 Korean patients with acute and chronic intestinal amoebiasis. In aute amoebic dysentry eight of ten patients given tinidazole 150 mg q.i.d. for 10 days were cured clinically and parasitologically. In chronic intestinal amoebiasis, the parasitological cure was obtained 6 out of 10 patients given150 mg q.i.d. for 10 days and 8 out of 10 in patients given 300 mg q.i.d. for 7 days.

Tinidazole is well tolerated and is free from serious toxicity. There was no significant alteration in blood count, liver function tests and urine analysis of any of the patients treated with tinidazole.


Table 1
Incidence of intestinal protozoa on a group of 370 rural inhabitants in Korea.

Table 2
Results of treatment with tinidazole.

1. Andersson T, Forssell J, Sterner G. Outbreak of giardiasis: effect of a new antiflagellate drug, tinidazole. Br Med J 1972;2(5811):449–451.
2. Antani J, Srinivas HV. Clinical evaluation of metronidazole in hepatic amebiasis. Am J Trop Med Hyg 1970;19(5):762–766.
3. Catizone F, et al. Gazz Int Med Chir 1970;75(17):1313–1320.
4. Chhetri MK, Chakravarty NC, Bhattacharya B, Sarkar SK. Further experience with metronidazole in the treatment of intestinal and hepatic amoebiasis. J Indian Med Assoc 1968;51(6):277–281.
5. Daels J, et al. Tijdschr voor Geneeskunde 1970;15:747–756.
6. Dubois P, Lambotte R, Plomteux G. [Clinical therapeutic trial of Fasigyn in vaginal trichomoniasis]. Rev Med Liege 1970;25(18):586–590.
7. Khambatta RB. Metronidazole in chronic intestinal amoebiasis. Ann Trop Med Parasitol 1968;62(2):139–142.
8. O'Holohan DR, Hugoe-Matthews J. Single-dose and short course regimens of metronidazole in the treatment of amoebiasis in Malaysia. Ann Trop Med Parasitol 1972;66(2):181–186.
9. Park JI, et al. Korean J Intern Med 1973;16(3):213–216.
10. Powell SJ, MacLeod I, Wilmot AJ, Elsdon-Dew R. Metronidazole in amoebic dysentery and amoebic liver abscess. Lancet 1966;2(7477):1329–1331.
11. Powell SJ, Wilmot AJ, Elsdon-Dew R. Further trials of metronidazole in amoebic dysentery and amoebic liver abscess. Ann Trop Med Parasitol 1967;61(4):511–514.
12. Prakash O, Joshi DV, Vinayak VK, Dhingra PN, Tarachand A. The in vitro activity of tinidazole and other amoebicidal drugs on locally isolated strains of Entamoeba histolytica. Indian J Med Res 1970;58(7):845–853.
13. Rios ER, et al. Semana Med 1972;140:183–185.
14. Salem HH, Hayatee ZG, Awaness AM, Al-Allaf G. Oral dehydroemetine dihydrochloride in intestinal and hepatic amoebic disease. Trans R Soc Trop Med Hyg 1968;62(3):406–412.
15. Scott F, Miller MJ. Trials with metronidazole in amebic dysentery. JAMA 1970;211(1):118–120.
Editorial Office
Department of Molecular Parasitology, Samsung Medical Center, School of Medicine, Sungkyunkwan University,
2066 Seobu-ro, Jangan-gu, Suwon 16419, Gyeonggi-do, Korea.
Tel: +82-31-299-6251   FAX: +82-1-299-6269   E-mail: kjp.editor@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2022 by The Korean Society for Parasitology and Tropical Medicine.     Developed in M2PI