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Korean J Parasitol > Volume 11(1):1973 > Article

Original Article
Korean J Parasitol. 1973 Apr;11(1):54-60. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1973.11.1.54
Copyright © 1973 by The Korean Society for Parasitology
Efficacy of mass treatment for control of human filariasis
Joung Soon Kim,Ok Ryun Moon,Won Young Lee and Suk Lak Chun
Department of Epidemiology, School of Public Health, Seoul National University, Korea.

This study was carried out for three years from 1968 to 1970. Three coastal villages and four remote islets of Che Ju Island were surveyed and 90% of all inhabitants were blood smeared. These study areas were grouped into five according to its characteristic for evaluation of mass treatment with diethylcarbamazine citrate (Hetrazan U.S.P.) and insecticide spray in control of human filariasis. To set baseline up for control group, placebo was administered. Followings are the results obtained:

1. 81.1% of all mf positives accepted and completed the mass chemotherapy; main reason for refusal was side reactions told by neighboring villagers who experienced them.

2. 6 mg of hetrazan/kg B.W. × 12 doses given every day turned mf postives to mf negative in 92.1%. The patients who had high mf density remained mf positive in 16.5% whereas only 2.1% for low mf density.

3. 73.8% of mf positives after the treatment showed marked decrease in mf density. Most of them to less than 15n mg/20 mm3 of blood that can not infect mosquito effectively.

4. Mosquito infection rates were also dropped markedly in areas where mf positive were mass treated.

5. Side reaction induced by diethylcarbamazine was frequent(64%-90%) and various. The most frequent symptom was headache and fever.

6. DDT spray did not influence human mf rate and mosquito infection rate.


Table 1
Microfilaria rate by year, village, and control measures

Table 2
Result of mass treatment with Hetrazan* (the rate of turning positives to negative) by village

Table 3
The efficacy of the Hetrazan in relation to microfilaria density by village

Table 4
Change of microfilaria density in microfilaria positives before and after treatment with Hetrazan

Table 5
Mosquito infection rate by village, year and human mf rate

Table 6
The rate of side reaction among all patients treated with Hetrazan by village

Table 7
Symptoms of the side reaction induced by Hetrazan on 266 patients

1. Kim BC, et al. Korean J of Internal Med 1968;11(12):799–805.
2. Kim JS, Lee WY, Chun SL. Ecology of filariasis on Che Ju Island. Korean J Parasitol 1973;11(1):33–53.
3. Moon OR, et al. Korean J Public Health 1968;5(2):103–112.
4. Hewett RI, et al. JAMA 1947;135(11):708–712.
5. Sasa M, et al. Jpn J Exp Med 1959;29(5):369–405.
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