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Korean J Parasitol > Volume 10(2):1972 > Article

Original Article
Korean J Parasitol. 1972 Aug;10(2):79-85. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1972.10.2.79
Copyright © 1972 by The Korean Society for Parasitology
Santonin-kainic acid complex as a mass chemotherapeutic of Ascaris lumbricoides control in Korea
Soon Hyung Lee,Se Chul Kang,Jong Ho Ahn,Jung Woo Lee and Han Jong Rim
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.

Santonin-kainic acid complex was evaluated as a chemotherapeutic of the mass treatment of the Ascaris lumbricoides infection in Korea. The results could be summarized as follows:

1) The negative conversion rate was 82.9% in average in 4 treated groups. Some variations of negative conversion rate among the treated groups were noticed.

2) The egg reduciton rate was 97.7% in average and the results were rather uniform among the three evaluated groups.

3) By the analysis of egg reduction, it seems that the lightly infected cases whose E.P.G. were under 5,000 were resistant to treatment with the less reduced egg output.

4) After the treatment with this complex, the number of egg discharged cases were reduced to 1.84% and the average number of discharge eggs per incompletely treated or untreated cases were reduced to 12.5% compared with the level of before-treatment egg output.

5) The successive observations of the pattern of worm expulsion after drug intake was made. The worms were mostly expelled in the stool within 3 days, and 58.9% of total expelled worms were collected within 24-hour stool.

6) The minimum length of the immature worms expelled was 7.6cm. Among the 659 Ascaris collected in the first-day stool from 91 rural people, 8.5% were in the range of 7.6-12.2 cm-long, immature worms. The sex ratio, male: female=0.69:1.


Table 1
Egg negative conversion rates after treatment with santonin kainic acid complex against Ascaris lumbricoides infection without purgatives. The observation was made 2 weeks after administration.

Table 2
Egg reduction rates after treatment.

Table 3
Analysis of eff reduction rates in 185 cases.

Table 4
The distribution of E.P.G. by grades before and after treatment.

Table 5
The results of sucessive observations of pattern of Ascaris worm expulsion after drug administration.

Table 6
Measurements of the 659 worms collected from 91 rural cases after treatment.

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