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Korean J Parasitol > Volume 4(1):1966 > Article

Original Article
Korean J Parasitol. 1966 Aug;4(1):11-20. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1966.4.1.11
Copyright © 1966 by The Korean Society for Parasitology
Experimental studies of 1, 4-Bis-trichlormethyl-benzol on the infection of Clonorchis sinensis(I)
Kee-Mok Cho,Chong-Hwan Kim,Yung-Kyum Ahn and Chin-Thack Soh
Department of Parasitology, College of Medicine, Yonsei University, Korea.

The efficacy and toxicity of 1, 4-Bis-trichlor-methyl-benzol were examined in the animal infections(rat, rabbit and mouse) of Clonorchis sinensis.

1) The effective dosages to kill the worm in bile ducts were 1 × 150 mg/kg in rat and 5 × 150 mg/kg in rabbit.

2) During 48 to 72 hours after the administration of the drug, the inactive posteriorly swollen worms and variously degenerated worms were observed from liver ducts, gallbladder and intestine of the experimental animals. In gall bladder of rabbits, a plenty of fragments of the worms and clewed mass of eggs were confirmed under microscope.

3) The E.P.G. was not decreased to zero in 3 weeks observation after the administraiton of the drug except rabbit No. 9 which was treated with the dose of 5 × 250 mg/kg.

4) Minimal congestion and mild cloudy swelling of liver were observed in the groups of mice which were given 5 × 150 kg and 3 × 500mg/kg of the drug respectively.

5) The body weight of experimental animals showed no evidence of changes.


Ph. 1
Degenerated worm Note the posterior portion. Rat No. 4.

Ph. 2
Posterior part of the above worm. Note the degenerated testis.

Ph. 3
Seminal receptacle of the above worm.

Ph. 4
The contents of gall bladder of rabbit No. 5 showing colloidal aggulutination.

Ph. 5
The same as above(magnified)

Ph. 6
The same as above(magnified)

Ph. 7
Oral sucker of the worm recovered in liver ducts of rabbit No. 8.

Ph. 8
The contents of gall bladder of rabbit No. 8.

Ph. 9
The same as Ph. 8 (magnified)


Table 1
Eggs of Clonorchis sinensis in rats which were treated with Hetol

Table 2
Number of Clonorchis sinensis in autopsied rats which were treated with Hetol (dose : 1 × 150mg/kg)

Table 3
Number of eggs after the oral administration of Hetol to the C. sinensis infected rabbits given 500 metacercariae

Table 4
Number of Clonorchis sinensis in autopsied rabbits which were recovered after the adminstration of Hetol

Table 5
Change of body weight before and after the administration of Hetol

Table 6
Pathological changes of liver and kidney after the administration of Hetol

1. Laemmler G. Dtsch Tierarztl Wschr 1961;68(6):169–172.
2. Laemmler G. Zschr F Tropenmed U Parasit 1964;15(1-3):95–123. 164–199, 337–368.
3. Plotnikov NN, et al. Helm Abst 1964;33(6):676–681.
4. Yokogawa M, et al. Jap Jour Parasit 1965;14(3):233–242.
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