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Korean J Parasitol > Volume 36(2):1998 > Article

Original Article
Korean J Parasitol. 1998 Jun;36(2):121-125. English.
Published online Jun 20, 1998.  http://dx.doi.org/10.3347/kjp.1998.36.2.121
Copyright © 1998 by The Korean Society for Parasitology
Immunosuppressive effect of Cryptosporidium baileyi infection on vaccination against Newcastle disease in chicks
J K Rhee,*H C Kim,S B Lee and S Y Yook
Bio-Safety Research Institute, Chonbuk National University, Chonju 561-756, Korea.
Received February 28, 1998; Accepted April 14, 1998.


Hemagglutination-inhibition titers (log2) to Newcastle disease (ND) virus were chronologically observed in chicks, which were orally inoculated with 5 × 105 oocysts of Cryptosporidium baileyi at 2 days of age and subsequently vaccinated with inactivated ND virus at 4 and 21 days postinoculation. In general, the titers were considerably lower in the infected chicks than those in the uninfected control throughout the experimental period (p < 0.01), and rapid negative seroconversions were observed in the infected chicks. The titers reached a peak on weeks 2 and 4 post-booster-vaccination in the control and infected chicks, respectively. Thus, C. baileyi infection was shown to have an immunosuppressive effect on ND vaccination when the agent was given to 2-day-old chicks. It is suggested that C. baileyi infection in chicks may increase the host susceptibility to ND virus.


Table 1
Fluctuations of hemagglutination-inhibition titers (log2) after vaccination against Newcastle disease in Cryptosporidium baileyi infected chicksa)

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