Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81

Warning: fopen(upload/ip_log/ip_log_2024-03.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83

Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84
Effects of Cryptosporidium muris (strain MCR) infection on gastric mucosal mast cells in mice
| Home | E-Submission | Sitemap | Contact us |  
top_img
Korean J Parasito Search

CLOSE

Korean J Parasito > Volume 35(4):1997 > Article

Original Article
Korean J Parasitol. 1997 Dec;35(4):245-249. English.
Published online Dec 20, 1997.  http://dx.doi.org/10.3347/kjp.1997.35.4.245
Copyright © 1997 by The Korean Society for Parasitology
Effects of Cryptosporidium muris (strain MCR) infection on gastric mucosal mast cells in mice
J K Rhee,*C G Surl and H C Kim
Department of Parasitology, School of Veterinary Medicine, Chonbuk National University, Chonju 561-756, Korea.
Received October 04, 1997; Accepted November 17, 1997.

Abstract

The responses of gastric mucosal mast cells (GMMCs) to infection with coccidian protozoa, Cryptosporidium muris, in mice were examined during primary and challenge infections. Each of three-week old ICR SPF mice was orally inoculated with a single dose of 2 × 106 oocysts of C. muris (strain MCR). After oocyst shedding ceased, the mice were orally challenged with a single dose of 2 × 106 oocysts of the same species. GMMCs reached a peak on days 20-30 postinoculation (PI) in number, and decreased thereafter. An increase on days 20-30 post-challenge-infection (PCI) was also observed. The mice showed, on the whole, normal profiles of oocyst shedding in droppings. The number of the cells of uninfected control mice remained constant. Judging from the above results, it is suggested that mastocytosis correlate with expulsion of C. muris in primary infection and the defense mechanism of challenge infection.

Figures


Fig. 1
Pattern of oocyst shedding in mice primarily inoculated with 2 × 106 oocysts of C. muris (strain MCR). (+) and (-) indicate that less than 103 oocysts were detected and oocysts were not detected, respectively.

Tables


Table 1
Fluctuations in numbers of gastric mucosal mast cells in mice infected with Cryptosporidium muris (strain MCR)

References
1. Chai JY, Kim TH, Kho WG, Chung SW, Hong ST, Lee SH. Mucosal mast cell responses to experimental Metagonimus yokogawai infection in rats. Korean J Parasitol 1993;31(2):129–134.
  
2. Crowle PK, Reed ND. Rejection of the intestinal parasite Nippostrongylus brasiliensis by mast cell-deficient W/Wv anemic mice. Infect Immun 1981;33(1):54–58.
 
3. Erlich JH, Anders RF, Roberts-Thomson IC, Schrader JW, Mitchell GF. An examination of differences in serum antibody specificities and hypersensitivity reactions as contributing factors to chronic infection with the intestinal protozoan parasite, Giardia muris, in mice. Aust J Exp Biol Med Sci 1983;61:599–615.
  
4. Finkelman FD, et al. Parasit Today 1991;7(3):A62–A65.
 
5. Ghadirian E, Meerovitch E. Parasit Immunol 1983;5(4):369–376.
 
6. Harp JA, Moon HW. Susceptibility of mast cell-deficient W/Wv mice to Cryptosporidium parvum. Infect Immun 1991;59(2):718–720.
 
7. Huntley JF, Newlands GF, Miller HR, McLauchlan M, Rose ME, Hesketh P. Systemic release of mucosal mast cell protease during infection with the intestinal protozoal parasite, Eimeria nieschulzi. Studies in normal and nude rats. Parasite Immunol 1985;7(5):489–501.
  
9. Lee TDG, et al. Parasit Today 1986;2(7):186–191.
 
10. Mosmann TR, et al. Ann Rev Immunol 1989;7:145–173.
 
11. Rhee JK, Kim HC, Park BK. Effects of Cryptosporidium baileyi infection on the bursa of Fabricius in chickens. Korean J Parasitol 1997;35(3):181–187.
  
12. Jk Rhee,et al. Korean J Vet Res 1994;34(3):559–567.
13. Rhee JK, Park BK, Seu YS. [Effects of immunoactivity on Ascaris suum infection in mice]. Korean J Parasitol 1991;29(3):279–291.
 
14. Rhee JK, Youk SY, Park BK. [Effect of Hymenolepis nana infection on immunological responses of mice to sRBC]. Korean J Parasitol 1989;27(1):23–33.
 
15. Rhee JK, Yook SY, Park BK. Oocyst production and immunogenicity of Cryptosporidium muris (strain MCR) in mice. Korean J Parasitol 1995;33(4):377–382.
  
16. Rose ME, Hesketh P. Coccidiosis: T-lymphocyte-dependent effects of infection with Eimeria nieschulzi in rats. Vet Immunol Immunopathol 1982;3(5):499–508.
  
17. Rose ME, Millard BJ, Hesketh P. Intestinal changes associated with expression of immunity to challenge with Eimeria vermiformis. Infect Immun 1992;60(12):5283–5290.
 
18. Rose ME, Ogilvie BM, Bradley JW. Intestinal mast cell response in rats and chickens to coccidiosis, with some properties of chicken mast cells. Int Arch Allergy Appl Immunol 1980;63(1):21–29.
  
19. Urban JF Jr, Madden KB, Svetic A, Cheever A, Trotta PP, Gause WC, Katona IM, Finkelman FD. The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev 1992;127:205–220.
  
20. Woodbury RG, Miller HR, Huntley JF, Newlands GF, Palliser AC, Wakelin D. Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rat. Nature 1984;312(5993):450–452.
  
Editorial Office
Department of Molecular Parasitology, Samsung Medical Center, School of Medicine, Sungkyunkwan University,
2066 Seobu-ro, Jangan-gu, Suwon 16419, Gyeonggi-do, Korea.
Tel: +82-31-299-6251   FAX: +82-1-299-6269   E-mail: kjp.editor@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2024 by The Korean Society for Parasitology and Tropical Medicine.     Developed in M2PI