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Korean J Parasitol > Volume 33(2):1995 > Article

Brief Communication
Korean J Parasitol. 1995 Jun;33(2):131-134. English.
Published online Jun 20, 1995.  http://dx.doi.org/10.3347/kjp.1995.33.2.131
Copyright © 1995 by The Korean Society for Parasitology
Lymphadenitis in experimental murine toxoplasmosis induced by intramuscular injection of tachyzoites
Won-Young Choi,*Ho-Woo Nam,Eun-Jung Baek and Seung-Yull Cho
Department of Parasitology, Catholic University Medical College, Seoul 137-701, Korea.
Received May 06, 1995; Accepted May 19, 1995.


When tachyzoites (RH strain) of Toxoplasma gondii are injected intramuscularly, experimental mice survive up to 7 days, 1-2 days longer than those infected intraperitoneally. We observed sequential histopathological changes in inguinal lymph nodes after intramuscular injection of tachyzoites to thighs of specific pathogen free (SPF) mice. Initial findings on 1 or 3 days after the injection were reactive germinal centers, distended sinuses and epithelioid cell clusters in cortical and paracortical regions. Later on 5 days after the injection, however, effacement of nodal structure with depletion of cells and focal necrosis were observed. Necrotizing lymphadenitis in the experimental murine toxoplasmosis suggests the causal relation between T. gondii infection and the human disease.


Figs. 1-4
Ipsilateral murine inguinal lymph nodes after the intramuscular injection of tachyzoites to thigh. Hematoxylin-eosin stained, × 40. 1. Control lymph node of non-injected specific pathogen free mouse. 2. Lymph node of one day after the injection. Secondary follicles are well developed in cortical region. 3. Lymph node of 3 days after the injection. Follicular structures disappeared, and lymph sinuses are tortuously expanded and filled with many monocyte-like cells. 4. Lymph node of 5 days after the infection. Lymph nodes are enlarged about 1.5-2 times of non-injected controls. Nodal architecture was diffusely damaged with focal necrosis.


Table 1
The number of ipsilateral and contralateral inguinal lymph nodes of mice which demonstrate specific histopathological findings of toxoplasmic lymphadenitis. Each group consists of 5 mice

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