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Korean J Parasitol > Volume 30(3):1992 > Article

Original Article
Korean J Parasitol. 1992 Sep;30(3):169-175. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1992.30.3.169
Copyright © 1992 by The Korean Society for Parasitology
Egg production of Clonorchis sinensis in different strains of inbred mice
J I Kim,D I Chung and D W Choi
Department of Parasitology, School of Medicine, Kyungpook National University, Taegu 700-422, Korea.

In order to compare the intraspecific variation in host-parasite relationship of Clonorchis sinensis, six strains of inbred mice, ICR, DDY, GPC, BALB/c, nude and DS, were infected orally with 20 metacercariae of C. sinensis. The biologic incubation period of C. sinensis was the shortest in DDY mice, 21.2 days in average, followed by GPC 21.4, BALB/c and DS 23.2, ICR and nude 23.4 days, respectively. The fertile period of the fluke was also the longest in the DDY strain, 164 days on average, followed by GPC 132, BALB/c 97, nude 37, DS 32 and ICR 28 days. The egg-laying capacity of the fluke in DDY and GPC was relatively high and stable compared with the other four strains of mice. It was found that there are intraspecific variations in biologic incubation period, fertile period, and fecundity of C. sinensis. The DDY mouse is likely to be the most suitable experimental animal among the six strains of the mice tested.


Fig. 1
Eggs per gram of BALB/c and nude feces during the experimental infection period.

Fig. 2
Eggs per gram of GPC and ICR feces during experimental infection.

Fig. 3
Eggs per gram of DDY and DS feces during the experimental infection period.


Table 1
Biologic incubation period of Clonorchis sinensis in inbred strains of mice after experimental infection with 20 metacercariae of C. sinensis

Table 2
Fertile period of C. sinensis in inbred strains of mice infected with 20 metacercariae of C. sinensis

Table 3
Eggs per gram of mouse feces (EpG) during experimental infection period

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