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Korean J Parasitol > Volume 26(1):1988 > Article

Original Article
Korean J Parasitol. 1988 Mar;26(1):15-26. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1988.26.1.15
Copyright © 1988 by The Korean Society for Parasitology
Intracranial synthesis of specific IgG antibody in cerebrospinal fluid of neurocysticercosis patients
Seung-Yull Cho,Suk Il Kim,Shin Yong Kang and Ae Ja Park*
Department of Parasitology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
*Department of Clinical Pathology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.

To determine the source of Cysticercus-specific IgG antibody in cerebro-spinal fluid(CSF), paired samples of serum and CSF were collected from confirmed neurocysticercosis, other neurologic diseases and normal control. The antibody levels in serum and CSF were measured by enzyme-linked immunosorbent assay (ELISA). With the measurement of total protein, albumin and IgG concentration in serum and CSF, the contribution of IgG in CSF were calculated in transudation, exudation and intracranial synthesis using the formula of Tourtellotte and Ma (1978). Mean concentrations of total protein, albumin, IgG and proportional IgG levels in CSF by transudation, exudation and intracranial synthesis were elevated in neurocysticercosis. But only the intracranial synthesis of IgG showed a statistically significant correlation with the specific IgG antibody levels in CSF. In CSF from lateral ventricle in the 4th ventricular neurocysticercosis, the protein concentrations were normal and the specific antibody levels were negative. However, in consecutively secured lumbar CSF from the same patients, the former were increased and the latter were positive. These results indicated that, in neurocysticercosis, the specific IgG antibody in CSF was a local product of intracranial synthesis.


Fig. 1
Relationship between abs. of specific IgG antibody in CSF and claculated contribution of CSF IgG by transudation, exudation and intracranial synthesis. Closed circle (•): a neurocysticercosis patients of serum (+), open circle (◦): a patient of serum (-).


Table 1
Results of Cysticercus-specific IgG antibody tests in serum and CSF by ELISA in subjected patients

Table 2
Mean±SD of protein measurements, calculated contribution of IgG in CSF and abs. of specific IgG antibody in serum and CSF of the subjected patients

Table 3
Relationship between total protein concentration and specific IgG antibody levels in CSF

Table 4
Relationship between albumin concentration and specific IgG antibody levels in CSF

Table 5
Relationship between IgG concentration and specific IgG antibody levels in CSF

Table 6
Comparison of protein profiles and specific IgG antibody levels in 5 ventricular CSF and 3 paired lumbar CSF in nuerocysticercosis patients with the 4th ventricle lesions

Table 7
Association of exudation with intracranial synthesis of IgG in CSF in neurocysticercosis patients

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