| Home | E-Submission | Sitemap | Contact us |  
Korean J Parasitol > Volume 26(1):1988 > Article

Original Article
Korean J Parasitol. 1988 Mar;26(1):1-8. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1988.26.1.1
Copyright © 1988 by The Korean Society for Parasitology
Changes of anti-Clonorchis sinensis IgG antibody in serum after praziquantel treatment in human clonorchiasis
Sung Tae Hong
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Seoul, 110-460, Korea.

Anti-Clonorchis IgG antibody levels in serum were observed by ELISA in 129 egg positive cases and in 25 controls. The antibody levels were 0.063 to 1.216 (0.325±0.202)in clonorchiasis cases and 0.078 to 0.670 (0.255±0.133) in controls. The difference was statistically significant. However, serological diagnosis of clonorchiasis was not satisfactory in lightly infected cases because of low levels of specific IgG antibody. The antibody levels were well correlated with EPG. Changes of the IgG antibody levels were not significant 12-14 days, 4 weeks and 8-9 weeks after praziquantel treatment. Seven and 13 months after treatment, the IgG antibody levels were lowered significantly. The period for serologically negative conversion after praziquantel treatment was between 9 weeks and 7 months in human clonorchiasis.


Fig. 1
Anti-Clonorchis IgG antibody levels by ELISA plotted by grade of EPG.

Fig. 2
Changes of Anti-Clonorchis IgG antibody levels in serum by ELISA after treatment by Group(Group I-C; pre-treatment of Group I, I-T; 12-14 days after treatment, Group II-C; pre-treatment of Group II, II-T; 4-6 weeks after treatment, Group III-C; pre-treatment of Group III, III-T; 8-9 weeks after treatment, Group IV-C; pre-treatment of Group IV, IV-T; 7 months after treatment, Group V-C; pre-treatment of Group V, V-T; 13 months after treatment).


Table 1
Anti-Clonorchis IgG antibody levels by ELISA in C. sinensis egg positive cases and controls

Table 2
Anti-Clonorchis IgG antibody levels in serum by EPG grades in clonorchiasis cases

Table 3
Changes of anti-Clonorchis IgG antibody after praziquantel treatment in various groups

1. Cho SY, Hong ST, Rho YH, Choi SY, Han YC. Application of micro-ELISA in serodiagnosis of Human paragonimiasis. Korean J Parasitol 1981;19(2):151–156.
2. Cho SY, Kim SI, Kang SY, Choi DY, Suk JS, Choi KS, Ha YS, Chung CS, Myung HJ. Evaluation of enzyme-linked immunosorbent assay in serological diagnosis of human neurocysticercosis using paired samples of serum and cerebrospinal fluid. Korean J Parasitol 1986;24(1):25–41.
3. Cho SY, Kim SI, Kang SY. Serologic follow-up study in neurocysticercosis patients by ELISA after praziquantel treatment. Korean J Parasitol 1986;24(2):159–170.
4. Choi WY, Yoo JE, Nam HW, Choi HR. [Purification of antigenic proteins of Paragonimus westermani and their applicability to experimental cat paragonimiasis]. Korean J Parasitol 1986;24(2):177–186.
5. Ham JH, et al. Korea Univ Med J 1984;21(1):177–184.
6. Han JH, et al. Korea Univ Med J 1986;23(1):13–25.
7. Kim H, Kim SI, Cho SY. Serological Diagnosis Of Human Sparganosis By Means Of Micro-ELISA. Korean J Parasitol 1984;22(2):222–228.
8. Kim HD, et al. Korea Univ Med J 1987;27(3):107–116.
9. Lee JK, et al. Yonsei J Med Sci 1981;14(1):133–146.
10. Lee KH, et al. Korea Univ Med J 1986;23(3):13–22.
11. Lee SH. Large scale treatment of Clonorchis sinensis infections with praziquantel under field conditions. Arzneimittelforschung 1984;34(9B):1227–1230.
12. Lee SH, Hong ST, Kim CS, Sohn WM, Chai JY, Lee YS. Histopathological changes of the liver after praziquantel treatment in Clonorchis sinensis infected rabbits. Korean J Parasitol 1987;25(2):110–122.
14. Lee SH, Park HJ, Hong SJ, Chai JY, Hong ST. In vitro effect of praziquantel on Paragonimus westermani by light and scanning electron microscopic observation. Korean J Parasitol 1987;25(1):24–36.
15. Lee YK, Ryu JS, Lee KT, Im KI. [Comparison Of Tia With ELISA For Circulating Antibody Detection In Clonorchiasis]. Korean J Parasitol 1983;21(2):265–269.
16. Matsuda H. Jpn J Parasitol 1984;33(3):163–170.
17. Rim HJ. The current pathobiology and chemotherapy of clonorchiasis. Korean J Parasitol 1986;24 Suppl:1–141.
18. Rim HJ, Lyu KS, Lee JS, Joo KH. Clinical evaluation of the therapeutic efficacy of praziquantel (Embay 8440) against Clonorchis sinensis infection in man. Ann Trop Med Parasitol 1981;75(1):27–33.
19. Roberts SM, Wilson RA, Ouma JH, Kariuki HC, Koech D, arap Siongok TK, Sturrock RF, Butterworth AE. Immunity after treatment of human schistosomiasis mansoni quantitative and qualitative antibody responses to tegumental membrane antigens prepared from adult worms. Trans R Soc Trop Med Hyg 1987;81(5):786–793.
20. Seo BS, Lee SH, Chai JY, Hong ST. Praziquantel(Distocide(R)) In Treatment Of Clonorchis Sinensis Infection. Korean J Parasitol 1983;21(2):241–245.
21. Soh CT, et al. Yonsei Rep Trop Med 1985;16(1):1–10.
22. Sturrock RF, Bain J, Webbe G, Doenhoff MJ, Stohler H. Parasitological evaluation of curative and subcurative doses of 9-acridanone-hydrazone drugs against Schistosoma mansoni in baboons, and observations on changes in serum levels of anti-egg antibodies detected by ELISA. Trans R Soc Trop Med Hyg 1987;81(2):188–192.
23. Tsuji M. Pre- and posttreatment serodiagnosis for paragonimiasis. Arzneimittelforschung 1984;34(9B):1204–1207.
24. Yang JS, et al. Korea Univ Med J 1983;20(1):201–210.
Editorial Office
Department of Molecular Parasitology, Samsung Medical Center, School of Medicine, Sungkyunkwan University,
2066 Seobu-ro, Jangan-gu, Suwon 16419, Gyeonggi-do, Korea.
Tel: +82-31-299-6251   FAX: +82-1-299-6269   E-mail: kjp.editor@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © 2022 by The Korean Society for Parasitology and Tropical Medicine.     Developed in M2PI