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Korean J Parasitol > Volume 25(2):1987 > Article

Original Article
Korean J Parasitol. 1987 Dec;25(2):149-153. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1987.25.2.149
Copyright © 1987 by The Korean Society for Parasitology
Specific IgG antibody responses in experimental cat metagonimiasis
Seung-Yull Cho,Suk Il Kim and Shin Yong Kang
Department of Parasitology, College fo Medicine, Chung-Ang University, Seoul 151, Korea.

In order to observe the feasibility of serologic diagnosis of metagonimiasis, saline extracts of metacercariae and 4-week old adults were prepared. Sera from 25 experimentally infected cats were collected from 3 days to 12 weeks after infection. Their levels of specific IgG antibody were measured by ELISA together with 3 sera from non-infected cats. Specific IgG antibody levels began to rise in 7 days after infection, reached their peak in 2-4 weeks and made a plateau thereafter. Cats infected with hundreds of adult worms showed minimal rise of the antibody level. Adult antigen was superior to metacercarial antigen in detecting the specific IgG antibody.


Fig. 1
Specific IgG antibody levels in individual cat as measured by ELISA. Open triangle, circle and rectangle (▵, ◦, ▫) mean antibody levels to metacercarial antigen while closed ones (▴, •, ▪) mean those to adult antigen. Triangles (▵,▴): cats infected with less than 1,000, circles (◦, •): cats infected with 1,000~5,000, rectangles (▫, ▪): cats infected with more than 5,000 adults. Markings (◦, ▫) of B (in control cats) represents abs. to metacercarial (◦) or adult (▫) antigens.


Table 1
Specific IgG antibody levels as measured by ELISA in 25 experimental cats infected with different doses of Metagonimus yokogawai

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