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Korean J Parasitol > Volume 16(2):1978 > Article

Original Article
Korean J Parasitol. 1978 Dec;16(2):65-68. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1978.16.2.65
Copyright © 1978 by The Korean Society for Parasitology
Niclosamide in the treatment of tetagonimiasis
Yung-Kyum Ahn,Bong-Suck Chung and Chin-Thack Soh
Department of Parasitology, College of Medicine and Institute of Tropical Medicine, Yonsei University, Korea.
Abstract

Anthelmintic effect of niclosamide [N-(2-chloro-4-nitrophenyl)-5-chloro-salicylamide)] on Metagonimus infection was carried out to the cases in area of Seomjin-river. The drug, one tablet contains 0.5 g of niclosamide was supplied from Bu-gwang pharmaceutical company in Seoul.

Sixty five cases were divided into three groups by the regimen: Group l given 2 g(4 tablets) for one day, Group II for two successive days and Group III for three successive days. Stool examination was done before and 2-3 weeks after the drug administration by formalin-ether concentration and Stoll's dilution egg counting techniques.

The results were as follows:

Egg negative conversion (cured) and egg reduction (more than 80% decrease) rates were 28.6%, 10.7% in group I, and 31.8%, 27.3% in group II. But of those in group III treated for three successive days, 73.3% was cured and 26.7% showed egg reduction, and the general egg reduction rate was 95.1%.

The results in the present trial suggested that the niclosamide has anthelmintic efficacy when it is used in 2 g for more than three successive days.

Tables


Table 1
Age distribution of the infected cases with Metagonimus yokogawai by group


Table 2
E.P.G. ranges of the infected cases with Metagonimus yokogawai by group


Table 3
Efficacy of niclosamide in Metagonimus yokogawai infectedf cases


Table 4
Intensity of egg reduction after treatment with niclosamide

References
1. Chai JY, Cho SY, Seo BS. Study on Metagonimus yokogawai(Katsurada, 1912) in Korea: IV. An epidemiological investigation along Tamjin River basin, South Cholla Do, Korea. Korean J Parasitol 1977;15(2):115–120.
 
2. Perera DR, Western KA, Schultz MG. Niclosamide treatment of cestodiasis. Clinicial trials in the United States. Am J trop Med & Hyg 1970;19(4):610–612.
3. El-Rooby A, Ata AA, El-Badrawy N. A trial of preparation AI 307 in the treatment of dysenteries. J Trop Med Hyg 1962;65:120–124.
 
4. Perera DR, Western KA, Schultz MG. Niclosamide treatment of cestodiasis. Clinicial trials in the United States. Am J trop Med & Hyg 1970;19(4):610–612.
5. Seo BS, et al. Seoul J Med 1971;12(4):234–241.
6. Soh CT, et al. Yonsei Rept Trop Med 1976;7(1):74–76.
7. Soh CT, et al. Yonsei Rept Trop Med 1976;7(1):3–16.
8. Soh CT, Ahn YK. [Epidemiological Study On Metagonimus Yokogawai Infection Along Boseong River In Jeonra Nam Do, Korea]. Korean J Parasitol 1978;16(1):1–13.
 
9. Yeo TO, et al. Seoul J Med 1971;12(4):259–267.
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