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Intestinal pathologic findings at early stage infection by Centrocestus armatus in albino rats
S J Hong,*1J H Han,2C K Park,3 and S Y Kang1
1Department of Parasitology, Chung-Ang University College of Medicine, Dongjak-gu, Seoul 156-756, Korea.
Received January 27, 1997; Accepted March 20, 1997.
Abstract
This study was performed to observe intestinal pathology in early infection by Centrocestus armatus. The flukes were in the lowermost part of the intervillous space of the duodenum and jejunum from 1 day to 7 days postinfection (PI). The stroma of villi around the young fluke was edematous and infiltrated by inflammatory cells such as lymphocytes, plasma cells and eosinophils. The crypt became mildly hyperplastic and villi were moderately atrophied at 4 days PI. The intestinal lesion produced was confined to the areas around the fluke. The pathologic findings were not significantly different between 1,000 and 5,000 metacercariae infection groups. It is suggested that the lesion should be produced by mechanical destruction of the fluke on the enteroepithelial cells.
Figures
Figs. 1-4 Fig. 1. A young C. armatus is pinching the epithelium of the duodenum of a rat in group I at 1 day postinfection (PI). ×200. Fig. 2. At two days PI, a juvenile fluke is in a cave of a broadly fused villus in group I. ×100. Fig. 3. At four days PI, a fluke puts its oral sucker and circumoral spines into the crypt opening and embrasses the intestinal mucosa with its ventral concavity in the duodenum of a rat in group I. ×200. Fig. 4. At seven days PI, a fluke is found in the intervillous space of a fused villus, of which the tip is moderately edematous, in the jejunum in group II. ×100.
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